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ceftazidime/avibactam sodium

A combination preparation containing the third-generation cephalosporin ceftazidime and the sodium salt form of avibactam, a non-beta-lactam beta-lactamase inhibitor, with antibiotic and beta-lactamase inhibiting activity, respectively. Upon administration, ceftazidime binds to essential penicillin-binding proteins (PBPs) and inhibits cell wall synthesis in certain bacteria. Avibactam binds to and inactivates beta-lactamases, thereby protecting ceftazidime from degradation and increasing ceftazidime’s efficacy.

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Synonym:	CAZ-AVI ceftazidime-avibactam sodium
US brand name:	Avycaz

ceftazidime/avibactam sodium

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