NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

Patient Information
A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Anti-EGFR Monoclonal Antibody
Anti-Epidermal Growth Factor Receptor Monoclonal Antibody
C225 monoclonal antibody
cetuximab biosimilar CDP-1
cetuximab biosimilar CMAB009
cetuximab biosimilar KL 140
Chimeric Anti-EGFR Monoclonal Antibody
Chimeric Monoclonal Antibody C225
Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 gamma1-chain), disulfide with human-mouse monoclonal C225 kappa-chain, dimer
monoclonal antibody C225
US brand name:Erbitux
Abbreviation:Chimeric MoAb C225
Code name:C225