NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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chimeric fibril-reactive monoclonal antibody 111F4
A chimeric monoclonal antibody specifically targeting human immunoglobulin light chain (LC)-related fibrils, which may potentially be used in the treatment of light chain-associated (AL) amyloidosis. Upon administration, chimeric fibril-reactive monoclonal antibody 111F4 targets and binds to the amyloid-related, conformational epitope on LC-related fibrils. This inhibits fibrillogenesis, induces an Fc-mediated cellular inflammatory response, increases degradation and elimination of AL amyloidomas, and prevents systemic LC-associated amyloid deposits. In AL amyloidosis the amyloid fibrils are composed of immunoglobulin light chain fragments. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:c11-1F4 mAb
chimeric amyloid-reactive monoclonal antibody 111F4
mAb-11-1F4
Code name:111F4
11-1F4