cobolimab
A monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, cobolimab binds to TIM-3 expressed on certain T cells, including tumor infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, activates antigen-specific T lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction in tumor growth. TIM-3, a transmembrane protein and immune checkpoint receptor, is associated with tumor-mediated immune suppression.
| Synonym: | anti-TIM3 checkpoint inhibitor TSR-022 anti-TIM3 monoclonal antibody TSR-022 |
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| Code name: | TSR-022 |
| Chemical structure: | immunoglobulin G4, anti-(hepatitis A virus cellular receptor 2 (havcr2)) (humanized clone ABT2 gamma4-chain), disulfide with humanized clone ABT2 kappa-chain, dimer |