NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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coxsackievirus A21
A preparation of naturally occurring, oncolytic enterovirus, with potential antineoplastic activity. Upon administration, coxsackievirus V937 targets and binds to intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor (DAF), both cell surface molecules that are overexpressed on certain malignant cells. After entering the cells, coxsackievirus V937 replicates in these cancer cells, thereby causing cancer cell lysis. This results in a reduction of tumor cell growth. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Cavatak
Foreign brand name:Cavatak
Abbreviation:CVA21
Code name:V 937
V937
V-937