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dacetuzumab

A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B-lineage hematologic malignancies including multiple myeloma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, Hodgkin disease and acute lymphoblastic leukemia.

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Synonym:	anti-huCD40 mAb monoclonal antibody SGN-40
Code name:	huS2C6 SGN-40

dacetuzumab

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