dulanermin
A recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types.
| Synonym: | recombinant human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand recombinant TNF-related apoptosis-inducing ligand |
|---|---|
| Abbreviation: | RhApo2L/TRAIL |
| Code name: | AMG 951 |
| Chemical structure: | 114-281-protein TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) (synthetic human) human tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis- inducing ligand or Apo-2 ligand or CD253 antigen)-(114-281)-peptide (C-terminal part of the extracellular domain), noncovalent homotrimer |