echinomycin
A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis.
| Synonym: | bis-quinoline analogue echinomycin A levomycin quinomycin A |
|---|---|
| Code name: | BRN 0078671 SK 302B |
| Chemical structure: | N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide) |
| IND number: | 19671 |
| NSC code: | 526417 |