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eflornithine hydrochloride

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The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells.
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Synonym:2-difluoromethylornithine hydrochloride
alpha-difluoromethylornithine hydrochloride
eflornithine HCl
US brand name:Iwilfin
Vaniqa
Code name:MDL 71782
RMI-71782
Chemical structure:2-(difluoromethyl)-DL-ornithine hydrochloride, monohydrate
2-difluoromethyl-dl-ornithine, monohydrochloride, monohydrate
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