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etaracizumab

A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.
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Synonym:humanized monoclonal antibody MEDI-522
monoclonal antibody anti-alpha V beta 3 integrin MEDI-522
US brand name:Abegrin
Code name:MEDI-522
Chemical structure:immunoglobulin G1 (synthetic mouse NSO cell heavy chain variable region fragment), complex with immunoglobulin G1 (synthetic mouse NSO cell light chain variable region fragment)
immunoglobulin G1, anti-[human alphaVbeta3 (CD51/CD61, CD51/GPIIIa, CD51/platelet membrane glycoprotein IIIa, vitronectin receptor)] humanized monoclonal antibody MEDI-522 (hLM609); gamma1 heavy chain [humanized VH (Homo sapiens FR/Mus musculus CDR from clone LM609)-Homo sapiens IGHG1*03] (220-214')-disulfide with kappa light chain [humanized V-KAPPA (Homo sapiens FR/Mus musculus CDR from clone LM609)-Homo sapiens IGKC*01]; (226-226'':229-229'')-bisdisulfide dimer
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