etaracizumab
A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.
| Synonym: | humanized monoclonal antibody MEDI-522 monoclonal antibody anti-alpha V beta 3 integrin MEDI-522 |
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| US brand name: | Abegrin |
| Code name: | MEDI-522 |
| Chemical structure: | immunoglobulin G1 (synthetic mouse NSO cell heavy chain variable region fragment), complex with immunoglobulin G1 (synthetic mouse NSO cell light chain variable region fragment) immunoglobulin G1, anti-[human alphaVbeta3 (CD51/CD61, CD51/GPIIIa, CD51/platelet membrane glycoprotein IIIa, vitronectin receptor)] humanized monoclonal antibody MEDI-522 (hLM609); gamma1 heavy chain [humanized VH (Homo sapiens FR/Mus musculus CDR from clone LM609)-Homo sapiens IGHG1*03] (220-214')-disulfide with kappa light chain [humanized V-KAPPA (Homo sapiens FR/Mus musculus CDR from clone LM609)-Homo sapiens IGKC*01]; (226-226'':229-229'')-bisdisulfide dimer |