NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. Check for active clinical trials using this agent. (NCI Thesaurus)

Code name:McN-R-1967
Chemical structure:
  • 4-(all-trans-retino-yl)aminophenol
  • 4-hydroxyphenylretinamide
  • All-trans-4'-hydroxyretinanilide
  • all-trans-N-(4-hydroxyphenyl)retinamide
  • all-trans-N-4'-hydroxyretinanilide
  • N-(4-hydroxyphenyl)retinamide