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fluciclovine F18

A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluciclovine F18 appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occurring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, fluciclovine F18 accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET).
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Synonym:(18F)fluciclovine
18F-fluciclovine
anti-(18f)FABC
anti-1-amino-3-[18F ]fluorocyclobutane-1-carboxylic acid
anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid
fluciclovine (18F)
US brand name:Axumin
Abbreviation:[18F]FACBC
anti-[18F] FACBC
Code name:(18F)GE-148
GE-148 (18F)
GE-148 F-18
Chemical structure:(1R,3R)-1-amino-3(18f)fluorocyclobutane-1-carboxylic acid
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