flucytosine
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
| Synonym: | 5-fluorocytosine |
|---|---|
| US brand name: | Ancobon |
| Foreign brand name: | Alcobon Ancotil |
| Abbreviation: | 5-FC |
| Code name: | Ro 2-9915 Ro-2-9915 |
| Chemical structure: | 4-amino-5-fluoro-2(1H)-pyrimidinone |
| NSC code: | 103805 |