NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

fluorine F 18 L-glutamate derivative BAY94-9392
A radioconjugate composed of the radionuclide fluorine F 18 conjugated to the L-glutamate derivative, (S)-4-(3-fluoropropyl)-L-glutamic acid (FSPG), targeting the cystine/glutamate transporter protein (xCT or SLC7A11), which is a subunit of the transport system xc(-), with potential imaging activity upon positron emission tomography (PET). Upon intravenous administration, the FSPG moiety of BAY94-9392 specifically binds to xCT and BAY94-9392 is subsequently taken up by the cell via xc(-). Upon uptake, xc(-) activity can be assessed and tumor cells can be detected and imaged by PET. System xc(-), a sodium-independent, heterodimeric transporter, mediates the cellular uptake of cystine in exchange for intracellular glutamate at the plasma membrane; although, it will take up glutamate as well. Xc(-) shows increased activity in certain tumor cells compared to normal, healthy cells due to increased metabolic activity in tumor cells; it plays a key role in tumor cell proliferation, progression and chemoresistance as well as in the management of oxidative stress. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:(4S)-(3-[F-18]fluoropropyl)-L-glutamic acid
Code name:BAY94-9392
Chemical structure:
  • (4S)-4-(3-18F-fluoropropyl)-L-glutamate
  • (S)-4-(3-18F-fluoropropyl)-L-glutamic acid