NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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flutemetamol F-18
A radiopharmaceutical containing flutemetamol, a thioflavin derivative of Pittsburgh compound B (PiB) labeled with the radioisotope fluorine F18 that can be used to detect beta-amyloid deposition upon positron emission tomography (PET). After intravenous administration of flutemetamol F 18, the flutemetamol moiety selectively accumulates in and binds to cerebral fibrillar amyloid-beta in the brain. The fluorine F18 radioisotope moiety is detected using PET, which allows imaging and quantification of amyloid-beta density. Amyloid plaque deposition is linked to cognitive decline, including Alzheimer’s disease, and may be linked to chemotherapy-induced cognitive impairment (CICI). Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:[18F]flutemetamol
[18F]FPIB
[18F]GE-067
fluorine F 18 flutemetamol
US brand name:Vizamyl
Chemical structure:2-[3-(18F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol