flutemetamol F 18
A radiopharmaceutical containing flutemetamol, a thioflavin derivative of Pittsburgh compound B (PiB) labeled with the radioisotope fluorine F18 that can be used to detect beta-amyloid deposition upon positron emission tomography (PET). After intravenous administration of flutemetamol F 18, the flutemetamol moiety selectively accumulates in and binds to cerebral fibrillar amyloid-beta in the brain. The fluorine F18 radioisotope moiety is detected using PET, which allows imaging and quantification of amyloid-beta density. Amyloid plaque deposition is linked to cognitive decline, including Alzheimer’s disease, and may be linked to chemotherapy-induced cognitive impairment (CICI).
| Synonym: | [18F]flutemetamol [18F]FPIB [18F]GE-067 fluorine F 18 flutemetamol flutemetamol F-18 |
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| US brand name: | Vizamyl |
| Chemical structure: | 2-[3-(18F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol |