fotemustine
A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
| Foreign brand name: | Muphoran |
|---|---|
| Code name: | S 10036 |
| Chemical structure: | [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate |