NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials using this agent. (NCI Thesaurus)

Foreign brand name:Muphoran
Code name:S 10036
Chemical structure:
  • [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester
  • 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester
  • diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate