NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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gallium Ga 68-labeled PSMA-11
A radioconjugate composed of a human prostate specific membrane antigen (PSMA)-targeting ligand, Glu-urea-Lys(Ahx) (Glu-NH-CO-NH-Lys(Ahx)), conjugated, via the acyclic radiometal chelator N,N'-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N'-diacetic acid (HBED-CC), to the radioisotope gallium Ga 68, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of gallium Ga 68-labeled PSMA-11, the Glu-urea-Lys(Ahx) moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during PET imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:(68)Ga labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC
(68)Ga-labeled Glu-urea-Lys(Ahx)-HBED-CC
(68)gallium-PSMA ligand Glu-urea-Lys(Ahx)-HBED-CC
(68)Ga-PSMA ligand Glu-urea-Lys(Ahx)-HBED-CC
[68Ga] prostate-specific membrane antigen 11
[68Ga]GaPSMA-11
68Ga-DKFZ-PSMA-11
68Ga-HBED-CC-PSMA
68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC
68Ga-PSMA-11
Ga-68-labeled PSMA-11
gallium Ga 68 PSMA-11
gallium-68 PSMA ligand Glu-urea-Lys(Ahx)-HBED-CC
PSMA-HBED-CC GA-68