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NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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gemcitabine hydrochloride
Patient Information
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:difluorodeoxycytidine hydrochloride
US brand name:Gemzar
Infugem
Abbreviation:dFdCyd
Code name:FF 10832
LY188011
LY-188011
Chemical structure:
  • 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride
  • 2'deoxy-2',2'-difluorocytidine hydrochloride
  • 2'-deoxy-2',2'-difluorocytidine hydrochloride