gemcitabine hydrochloride
View Patient InformationThe hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
| Synonym: | difluorodeoxycytidine hydrochloride gemcitabine HCI |
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| US brand name: | Gemzar Infugem |
| Abbreviation: | dFdCyd |
| Code name: | LY-188011 LY188011 |
| Chemical structure: | 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride 2'-deoxy-2',2'-difluorocytidine hydrochloride 2'deoxy-2',2'-difluorocytidine hydrochloride 2'deoxy-2',2'-difluorocytidine, hydrochloride |
| NSC code: | 613327 |