Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

glucarpidase

View Patient Information
A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:carboxypeptidase-G2
US brand name:Voraxaze
Abbreviation:CPDG2
CPG2
IND number:4663
NSC code:641273
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search