NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

IL-2 plasmid DNA/lipid complex
An immunotherapeutic agent consisting of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed with a cationic lipid, 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE), in a 5:1 ratio. Due to the lipophilic nature of this cation liposome complex, this gene transfer system may improve the efficiency of introducing the IL-2 gene into the cells, thereby increasing the production of IL-2 and inducing an immune response. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:IL-2 plasmid DNA/DMRIE/DOPE lipid complex
interleukin-2 DNA/lipid complex
plasmid DNA IL-2 lipid complex
US brand name:Leuvectin
Code name:VCL-1102