NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways. Check for active clinical trials using this agent. (NCI Thesaurus)

L-alanosine sodium
Code name:SDX-102
Chemical structure:
  • 3-(hydroxynitrosoamino)-L-alanine
  • L-2-amino-3-(hydroxynitrosoamino)propionic acid
  • L-2-amino-3-[(N-nitroso)hydroxylamino]propionic acid