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LMB-1 immunotoxin

A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2.

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Synonym:	B3-NLysPE38 immunotoxin LMB-1
Abbreviation:	LMB-1
NSC code:	651311

LMB-1 immunotoxin

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