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LMB-7 immunotoxin

A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2.
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Synonym:B3(Fv)-PE38
B3(Fv)-PE38 Immunotoxin
HB21(Fv)PE40
immunotoxin LMB-7
LMB-7 (Single-Chain Immunotoxin)
IND number:5863
NSC code:658931
659639
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