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ONYX-015

An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of ONYX-015-mediated tumor cell cytotoxicity.
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Synonym:E1B 55kDa mutant adenovirus dl1520
Code name:CI-1042
IND number:7872
NSC code:688653
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