NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- mepivacaine hydrochloride
-
The hydrochloride salt form of mepivacaine, an amide-type local anesthetic agent. At the injection site, mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: Carbocaine
PolocaineChemical structure: 1-methyl-2',6'-pipecoloxylidide hydrochloride (SY), (1-methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride