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misonidazole

A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis.

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Code name:	Ro-07-0582
Chemical structure:	1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole
IND number:	13462 16288
NSC code:	261037

misonidazole

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