NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

MnSOD mimetic BMX-001
A third generation, cationic, lipophilic, manganese (Mn) and porphyrin-based mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with antioxidant and potential chemoprotective activities. Upon administration, MnSOD mimetic BMX-001 is internalized by cells and mimics the activity of MnSOD by scavenging reactive oxygen species (ROS), such as superoxide anion, hydrogen peroxide, and hydroxyl radical. This prevents oxidative damage to macromolecules such as DNA and minimizes oxygen free radical-related chemotoxicity in normal tissues. This agent was designed to be more lipophilic and less toxic than first and second generation Mn-porphyrin mimetics. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:manganese (III) ortho N-butoxyethylpyridylporphyrin
mitochondrial manganese superoxide dismutatse mimetic BMX-001
Code name:BMX-001
Chemical structure:
  • manganese butoxyethyl pyridyl porphyrin; Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (SY); MnTnBuOE-3-PyP 5+
  • manganese(5+), ((2,2',2'',2'''-(21H,23H-porphine-5,10,15,20-tetrayl-kappaN21,kappaN22,kappaN23,kappaN24)tetrakis(1-(2-butoxyethyl)pyridiniumato))(2-))-, chloride (1:5), (sp-4-1)-