NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- TORC1/TORC2 inhibitor ATG-008
An orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. TORC1/TORC2 inhibitor ATG-008 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently dysregulated in human cancers. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: mTOR kinase inhibitor CC-223 US brand name: TORKi Code name: ATG-008