muromonab-CD3
A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell subset, followed by cytokine release, and subsequently inhibition of T cell functions. This agent may cause the opsonization and elimination of CD3-positive T cells from the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction.
Synonym: | Anti-CD3 monoclonal antibody OKT3 MOAB OKT3 monoclonal antibody OKT3 OKT3 |
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US brand name: | Orthoclone OKT3 |
Abbreviation: | MOAB OKT3 |
IND number: | 2851 3546 3860 6883 |
NSC code: | 618843 |