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nelarabine

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An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells.
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US brand name:Arranon
Code name:506U78
GW506U78
Chemical structure:2-amino-6-methoxypurine arabinoside
2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine
IND number:52611
NSC code:686673
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