NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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neoantigen-based glioblastoma vaccine
A peptide-based, personalized glioblastoma cancer vaccine consisting of patient-specific glioblastoma-derived immunogenic mutated epitopes (neoantigens), with potential immunomodulating and antineoplastic activities. Vaccination with the neoantigen-based glioblastoma vaccine stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. Neoantigens are tumor-specific antigens derived from mutated proteins that are present only in a specific tumor. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:NeoVax (TM) glioblastoma vaccine
personalized neoantigen glioblastoma vaccine