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nitazoxanide

A synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism. PFOR enzyme reduces nitazoxanide, thereby impairing the energy metabolism. However, interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity. Nitazoxanide is active against Giardia lamblia and Cryptosporidium parvum.
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US brand name:Alinia
Chemical structure:benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-
salicylamide, N-(5-nitro-2-thiazolyl)-, acetate(ester)
NSC code:697855
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