NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

oblimersen sodium
The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:antidode G3139
bcl-2 antisense oligodeoxynucleotide G3139
BCL-2 antisense/G3139
G3139 antisense oligonucleotide
G3139 bcl-2 antisense oligo
G3139 bcl-2 antisense oligodeoxynucleotide
G3139 bcl-2 antisense oligonucleotide
US brand name:Genasense
Code name:G3139