oblimersen sodium
The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance.
| Synonym: | antidode G3139 augmerosen bcl-2 antisense oligodeoxynucleotide G3139 BCL-2 antisense/G3139 G3139 antisense oligonucleotide G3139 bcl-2 antisense oligo G3139 bcl-2 antisense oligodeoxynucleotide G3139 bcl-2 antisense oligonucleotide |
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| US brand name: | Genasense |
| Code name: | G3139 |
| NSC code: | 683428 |