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oblimersen sodium

The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance.
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Synonym:antidode G3139
augmerosen
bcl-2 antisense oligodeoxynucleotide G3139
BCL-2 antisense/G3139
G3139 antisense oligonucleotide
G3139 bcl-2 antisense oligo
G3139 bcl-2 antisense oligodeoxynucleotide
G3139 bcl-2 antisense oligonucleotide
US brand name:Genasense
Code name:G3139
NSC code:683428
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