NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

TORC1/TORC2 inhibitor ATG-008
An orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. TORC1/TORC2 inhibitor ATG-008 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently dysregulated in human cancers. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:mTOR kinase inhibitor CC-223
US brand name:TORKi
Code name:ATG-008