onvatilimab
A human monoclonal antibody against the protein V-domain immunoglobulin (Ig) suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative checkpoint regulatory and antineoplastic activities. Upon administration, onvatilimab targets and binds to VISTA. This inhibits VISTA signaling, abrogates the VISTA-induced suppression of T-lymphocyte-mediated immune responses, enhances cytotoxic T-cell responses against tumor cells and inhibits tumor cell growth. VISTA, mainly expressed on hematopoietic cells, plays a key role in immunosuppression.
| Synonym: | immunoglobulin G1, anti-(human protein Vista (v-domain immunoglobulin suppressor of T cell activation)) (human clone JNJ 61610588 gamma1-chain), disulfide with human clone JNJ WHO 10758 |
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| Code name: | CI 8993 CI-8993 CI8993 JNJ 61610588 JNJ-61610588 |