ormaplatin
A platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity.
| Synonym: | tetraplatin |
|---|---|
| Chemical structure: | tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))platinum |