picoplatin
A new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis.
| Code name: | AMD473 NX 473 ZD0473 |
|---|---|
| Chemical structure: | Cis-Amminedichloro (2-Methylpyridine) Platinum Platinum, Amminedichloro(2-methylpyridine)-, (SP-4-3) |