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piroxantrone

An anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity.

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Synonym:	oxanthrazole oxantrazole Piroxantrone HCl
Code name:	CI-942 PD-111815
Chemical structure:	Anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)
IND number:	29720
NSC code:	349174

piroxantrone

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