procarbazine hydrochloride
View Patient InformationThe hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
| Synonym: | ibenzmethyzin hydrochloride MIH hydrochloride PCB hydrochloride PCZ |
|---|---|
| US brand name: | Matulane |
| Foreign brand name: | Natulan Natulanar |
| Abbreviation: | PCB PCZ |
| Code name: | NCI-C01810 Ro 4-6467/1 |
| Chemical structure: | benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) |
| IND number: | 7180 |
| NSC code: | 77213 |