NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

procarbazine hydrochloride
Patient Information
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:ibenzmethyzin hydrochloride
MIH hydrochloride
PCB hydrochloride
US brand name:Matulane
Foreign brand name:Natulan
Code name:NCI-C01810
Ro 4-6467/1
Chemical structure:
  • benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
  • N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride
  • N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride
  • N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride
  • p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
  • p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)