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pyrazofurin

A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication.

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Synonym:	beta-pyrazomycin compound 47599 pirazofurin pyrazomycin
Code name:	47599
Chemical structure:	4-hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide pyrazole, -3-carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl
IND number:	12100
NSC code:	143095

pyrazofurin

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