NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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pyrazofurin
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:beta-pyrazomycin
compound 47599
pirazofurin
pyrazomycin
Code name:47599
Chemical structure:
  • 4-hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide
  • pyrazole, -3-carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl