pyrazofurin
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication.
| Synonym: | beta-pyrazomycin compound 47599 pirazofurin pyrazomycin |
|---|---|
| Code name: | 47599 |
| Chemical structure: | 4-hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide pyrazole, -3-carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl |
| IND number: | 12100 |
| NSC code: | 143095 |