NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

Patient Information
A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-VEGFR-2 fully human monoclonal antibody IMC-1121B
US brand name:Cyramza
Code name:IMC-1121B
Chemical structure:
  • immunoglobulin G1, anti-(human vascular endothelial growth factor receptor type VEGFR-2 extracellular domain) (human monoclonal IMC-1121B γ-chain), disulfide with human monoclonal IMC-1121B κ-chain, dimer
  • immunoglobulin G1, anti-(vascular endothelial growth factor receptor 2 (EC or protein-tyrosine kinase receptor Flk-1 or CD309 antigen) extracellular domain); human monoclonal IMC-1121B γ1 heavy chain (219-214')-disulfide with human monoclonal IMC-1121B κ light chain (225-225'':228-228'')-bisdisulfide dimer