recombinant human endostatin
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature.
| Synonym: | endostatin N-terminal-MGGSHHHHH-endostatin (human recombinant) recombinant endostatin |
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| US brand name: | rhEndostatin |
| Foreign brand name: | Endostar |