safingol
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.
| Synonym: | sphinganine |
|---|---|
| US brand name: | Kynacyte |
| Chemical structure: | 2-amino-1,3-dihydroxyoctadecane L-threo-dihydrosphingosine |