SarCNU
An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity.
| Chemical structure: | 2-chloroethyl-3-sarcosinamide-1-nitrosourea |
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