NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

selumetinib sulfate
Patient Information
The sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:selumetinib sulphate
US brand name:Koselugo
Code name:AZD6244 hydrogen sulfate
AZD6244 hydrogen sulphate
Chemical structure:
  • 1H-benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2- hydroxyethoxy)-1-methyl-, sulfate (1:1)
  • 1h-benzimidazole-6-carboxamide,5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2- hydroxyethoxy)-1-methyl-, sulphate (1:1)
  • 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H- benzimidazole-6-carboxamide sulfate
  • 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H- benzimidazole-6-carboxamide sulphate