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shark cartilage extract AE-941

A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.
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Synonym:Neovastat/AE-941
US brand name:Neovastat
Foreign brand name:Neovastat
Code name:AE-941
IND number:59439
NSC code:706456
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