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sodium thiosulfate

A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation.
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Synonym:disodium thiosulfate
sodium hyposulfate
sodium thiosulfate pentahydrate
thiosulfuric acid disodium salt
US brand name:cyanide antidote package
Sodothiol
Foreign brand name:S-Hydril
Abbreviation:STS
IND number:26045
NSC code:45624
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