NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:KOS-953
Chemical structure:
  • 17-allylamino-17-demethoxy-geldanamycin
  • 17-allyl-aminogeldanamycin
  • 17-demethoxy-17-(2-propenylamino)geldanamycin