NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A humanized monoclonal antibody directed against nerve growth factor (NGF), a modulator of nociceptor function, with potential analgesic activity. Tanezumab binds to NGF and prevents NGF binding to its high affinity, membrane-bound, catalytic receptor tropomyosin-related kinase A (TrkA), which is present on sympathetic and sensory neurons; reduced stimulation of TrkA by NGF inhibits the pain-transmission activities of these neurons. NGF, a neurotrophin, is critical to the growth and maintenance of sympathetic and sensory neurons. In addition, NGF may induce mast cells to release inflammatory proteins and may induce the upregulation of substance P and other pain-related peptides in sympathetic and sensory neurons. Upon neurotrophin binding, TrkA phosphorylates itself and members of the MAPK pathway, mediating the multiple neuronal effects of NGF. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-NGF monoclonal antibody RN624
Code name:RN624
Chemical structure:
  • Immunoglobulin G2, anti (human nerve growth factor) humanized mouse monoclonal N624 [Lys71,Ser330,Ser331]gamma 2 heavy chain (135-214')-disulfide with kappa light chain (223-23'':224-224'':227-227'':230-230'')-tetrakisdisulfide dimer
  • immunoglobulin G2, anti (human nerve growth factor)(human mouse monoclonal N624 heavy chain), disulfide with human mouse monoclonal RN624 light chain, dimer