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TLR7/8 agonist MEDI9197

A toll-like receptor type 7 and 8 (TLR7/8) agonist with potential immunostimulating and antitumor activities. Upon intratumoral administration, TLR7/8 agonist MEDI9197 binds to and activates TLR7 and 8, thereby stimulating antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of proinflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL) and B-lymphocyte immune responses. This may cause tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental roles in the activation of the immune system.
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Synonym:TLR7/TLR8 dual agonist MEDI9197
Toll-like receptor 7/8 agonist MEDI9197
Code name:3M 052
3M-052
MEDI 9197
MEDI9197
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